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Comment by rogerkirkness | Hacker News Reader

Dietary fibre is a GLP-1 agonist, so if people ate enough fibre for the amount of calories they ate, no one except those with thyroid disorders would be overweight. This drug won't help with thyroid disorders. This drug will have long term side effects that are as bad as being overweight. Therefore, this drug should not be necessary, except that people won't eat enough fibre.

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And so, how much dietary fiber would you have to consume to equal the GLP-1 equivalent dose of the drugs referenced in the article?

It's being studied now, but generally speaking the benefits start to taper around 120g a day in existing studies we have about fibre. So it's most likely 'At least 120g/day and possibly more depending on what we learn studying GLP-1 further.

In contrast:

> The Metamucil powder dosage for adults and adolescents ages 12 and older is 3.4 grams (1 serving), mixed with 8 ounces of water, up to 3 times a day. The mixture should be consumed immediately after preparing it.

So, you're talking about 35.3 times the recommended Metamucil dose?

If a dose of Metamucil is a teaspoon, and a typical canister has 180 doses, you're talking about approximately one fifth of the entire container -- per day?

And drinking 282 ounces of water per day to wash down all that Metamucil?

That seems medically dangerous to me....

Honestly it’s not worth bothering with him. He’s fat and convinced it’s irreversible without medical intervention and is caused by his genetics. You can’t convince emotional thinkers with logic

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