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We can probably assume that writing assembly for a machine the better part of 40 years old was not what the author had in mind when writing.

I hope you have already watched "Dragon Warrior by NEScardinality" that shows exactly what slight advantage is https://www.youtube.com/watch?v=Bgh30BiWG58&t=428s

This exploit the fact that the game use a PRNG instead of a true RNG, and can work regardless of whether the PRNG is a CSPRNG or not.

You could use Siphash as a CSPRNG, and I have an implementation in 6502 asm: https://github.com/secworks/siphash_6502