With respect to Chan Zuckerberg Science:

As an engineer who had worked for a number of years in biotech and med-tech, I find fault with the underlying assumption that one can build an organization out of bio-PI types and get anything out of it beyond a bunch of papers.

My hard-earned experience is tha the biology PI track selects against the technocratic leadership style necessary for the coordination of a large-scale effort.

My own stint in the field found most value with a small subset of fresh PhDs who were still mentally flexible enough to figure out how to do their research in a stackable and incremental way.

Unsurprisingly, most of these people stood very little chance of being hired as PIs, because their focus on efficiency made for worse short-term splashing.