Agreed, I also use both. NextDNS/PiHole are great because you can configure them as the root DNS providers at the router level and give everyone in your household and guests on WiFi a painless ad-free experience while layering uBlock on top for the sneakier ads like Youtube.

The only downside is email unsubscribe links. Those annoyingly tend to be on domains blocked by the various block lists NextDNS uses.