Turbulence is an obvious one. Downdrafts another. You can have a perfectly functional aircraft, but if the whole air column it's in goes down faster than the aircraft can climb, the aircraft will go down with the air column no matter what.
Reminds me of an Air Crash Investigation episode: some volcano had erupted, ash was high up in the air, air traffic control wasn't aware of this, and iirc it didn't show up on weather radar or similar systems (or on the planes' systems).
So it looked all clear. Meanwhile the whole plane was getting ash-blasted. To the point that paint was stripped, cockpit windows went from clear to matte, and ash attached itself to engine fan blades. Obviously trouble followed...
Bottom line: the environment a vehicle moves through, is always a factor. Sometimes an unpredictable, uncontrollable and/or hazardous one.