Some products don't have a "search, find and purchase immediately" pattern to sales. Especially when you move out of the B2C market.
Some businesses sales can look more like "Visit half a dozen different sites. Go away for a week and think. Visit best sites again. Go away for a few days and come to a decision. Visit final option, browse and purchase".
Tracking these multiple visits can be non-trivial/impossible since it may be different people and different browsers visiting the site at the different stages. It also leads to long lead-times for the effects that design changes make.
For more subtle effects, you need more observations, plain and simple; it doesn't matter how you do the math if you don't have the data to reach the significance levels you care about.