BTW, this isn't only a problem with `isearch`. I suspect that other multiple-simultaneous-keypresses tend to be hard on most people's hands. Which can be bad for your typing-oriented career, and for other humans uses of hands.
Some alternatives in Emacs:
* Try to press the modifier key(s) with one hand, and the non-modifier key with the other.
* If the modifier(s) require contorting in uncomfortable ways, consider whether moving from home row is easier.
* When an Emacs key sequence includes the "Meta" modifier (`M-`), consider whether pressing and releasing the Esc key first, and then doing the remaining key/combo, is easier.
* Make a better key binding. Examples:
(global-set-key [f5] 'call-last-kbd-macro)
(global-set-key [f12] 'undo)
(global-set-key [XF86Back] '(lambda ()
(interactive)
(other-window -1)))
* Learn fancier Emacs features which might mean not having to type this or not as often (keyboard macros is just one).* Use or write a function or package that automates the higher-level task. For writing your own, you can learn from one of these two manuals, and just start experimenting in your running Emacs: https://www.gnu.org/software/emacs/manual/html_node/eintr/ https://www.gnu.org/software/emacs/manual/html_node/elisp/