I think you could probably hack something together that does this with DYLD_INSERT_LIBRARIES (OSX's LD_PRELOAD) that would would hook the open system call and fcntl F_NOCACHE on the file descriptor before it hands it back to the application.
That they are is just speculation from someone whose taken his experience and projected it onto everybody.
Since he's a person who mucks around with random system settings (like the one in his article) there's no telling what previous damage he's done to cause this problem.
EDIT: I can't get either spotlight or time machine to show any cache polluting behavior at all, at least not in the way that I run them. I used "mdutil -E /" to force a re-index of my disk, and I kicked off an initial time machine backup on a secondary drive I had lying around. I see both backupd and mdworker doing a lot of disk reads using iotop, but top shows my inactive memory not really changing as drastically as I'd expect, like if I were to cat a giant file to /dev/null.
I hope Apple engineers are looking at this thread.