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You mean when the inside air pressure is low enough. Aircraft doors fit like a plug, held in by air pressure in the cabin. If you look when they are opened they all move inward first. This is why they can't be opened mid-flight.

At the point where they can be opened, the pressure differential is going to be so low that nothing bad is going to happen, other than maybe someone's bag in the exit row being blown out by the wind. Plus everyone should be strapped in at that point.

This happened just last year IIRC in Korea. Nothing was in serious danger (except maybe some travel schedules). A comment already described the mechanism and why that’s not really a thing to worry about.

unless the strong man is the one that wants to open the door.

i think i've heard of someone trying to open a door mid flight once though, so unless i'm poorly informed, let's not give the TSA ideas around mental health screenings before flights.