One, large, central weapon against a swarm of hundreds of small ones? It's a deadly assumption that an entire swarm would come from one direction, for example. Or that it would appear all at once. I'm sure volumes will be written about the strategies yet to come, but if what we've seen in the 20 years of occupation of Afghanistan and Iraq is anything to go by, asymmetric warfare is very effective at tying up resources.
Watching what the twichy youngins do with FPV drones gives me the heebiejeebies -- this has already transferred to battlegrounds in Ukraine, with some serious impacts (no pun intended).