I'm not sure I can be quite that specific, but there are some very well-established differences in the way men and women think, and the way the respond to stress. See here:

http://bible.org/seriespage/biological-basis-gender-specific... [1]

. . . particularly sections V and VII.

I wouldn't go so far as to say we know how gender affects brain chemistry specifically as it refers to programming, only that we know it does affect how we think, process information, and handle stress. And those things seem like they would be relevant. Don't they?

That is to say, I wouldn't say I know ALL of the differences between us are innate, only that I find it plausible that a lot of them are. And that I'm hesitant to treat statistically underrepresented women as necessarily a problem.

[1] You'll have to excuse the bible.org reference; the christian academic community seems to be about the only one in which one can have a serious conversation about innate differences between the genders without getting immediately taken out and shot. You have my assurance that the discussion in the article is interesting and scientific, and comes with copious footnotes to mainstream sources.