VM (and ancillary tools, like Personality Crisis and mairix)
* does a great of job displaying HTML messages. For the very few that it doesn't, one keystroke sends the message to my web browser running locally.
* sends URLs I select (all from the keyboard) to the web browser
* opens images and attachments
* auto-adjusts the From: line of outgoing messages depending on the recipient
* archives messages to various folders using various criteria
* searches my archived mail at lightning speed
Of course, I can write Emacs Lisp code of my own to extend any or all of the above.
VM isn't perfect. I'm sure that I could do all of the above with Gnus, and quite possibly am missing out on other features that VM lacks. Overall, though, I really feel like I have a superpower for email handling with it.