While it is incredible how far these compatibility layers have come, I've been working a lot with getting old games running on modern Windows and I'm continuously impressed at how few barriers there are. The amount of backwards compatibility built into the platform is staggering.
I would like to also shout out other projects like dgVoodoo, dxWnd, IPXWrapper, and the massive amount of work that's gone into sites like WSGF and PCGamingWiki. I've yet to run into a game I can't get working (and I've been going into some pretty obscure stuff) and the amount of work put into preservation is heartwarming to say the least.