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> psychedelics that don't activate 5-HT2B (associated strongly with aortic hypertrophy, i.e., your heart valves grow too big)

Do you have a source for that? I'm a cardiac sonographer and I've never heard of aortic hypertrophy.

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I hadn’t heard of it either but it does seem like there are some studies. https://link.springer.com/chapter/10.1007/978-3-030-55920-5_... Cardiac valvulopathy is likely not an adverse effect to consider when psychedelics are used occasionally but this may be different for “microdosing” which involves low doses of psychedelics taken daily or multiple times per week.

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