Hacker News Reader

Comment by deadlinermusic | Hacker News Reader

Why the fuck would anyone do this?

So they can try to be prepared for when such a mutation does arise in the wild? I agree it's incredibly risky, but...?

What does this gain them over hypothesizing that it can happen and working accordingly? Researchers always make this kind of claim but it’s bullshit. When we’re interested in making earthquake resistant structure we use shake tables, not full on earthquakes. When we want to make more fire resistant buildings we don’t go about making better fires. When we want to understand the harms of child sexual abuse we E: dom't go around raping children.

Everyone involved in this should be permanently barred from entering laboratories or working in the broader field at all. They can go become artesian lumberjacks or subsistence farmers.

> When we want to understand the harms of child sexual abuse we do go around raping children.

That's one way to go about it, I suppose.

Thank you.

That's an incredibly stupid analogy.

We don't allow people to make automatic weapons. We don't even allow people to buy automatic weapons manufactured under government license after something like 1980. We don't allow people to build nuclear weapons. You're not allowed to broadcast radio waves willy nilly. Fact is we restrict things people are allowed to do all over the place in many different areas of life for the purpose of public safety. Yet we have researchers doing GOF research creating lethal germs that can spread through the air and kill the majority of people exposed with simply institutional review board at most.

From a layman's perspective, the GOF research that may or may not have caused covid in the first place, never actually yeiled anything useful for the pandemic. I'm pretty pro research, but I haven't seen anything good come from GOF.

Cause it will likely happen in nature as well.

What selective pressure exists in nature to result in a virus like this naturally evolving?

Do terrorist cells count?

Selective evolutionary pressure is the mechanism. Mutants like this would be benign in a host (bats) and lethal in another species.

Viruses do not want to be 100% lethal or have rapid action. That is bad for their spread and longevity. If a virus always kills its host and does it quickly, how does the virus spread? A virus does better when it can incubate awhile, hopefully asymptomatically, while its host goes about normal business, while the viral load increases and the contagion can spread in the open.

By the time that symptoms are noticeable and debilitating, it's game over, because the host is going to notice, and curtail his activity, thus curtailing spread of the virus and limiting its longevity.

People were so afraid of Ebola, but its lethality was a key factor in limiting its spread and keeping it rather contained, geographically speaking. The main fear about COVID-19 was asymptomatic infection and the resultant spread from people who had no idea they were carriers, and that's why socal distancing and face mask mandates were so important.

Reply on news.ycombinator.com