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Comment by cjbgkagh | Hacker News Reader

Ever thought about going to the grey/black market? If the athletes can get it why can’t you? I could understand the reasons why you may not want to. I have chronic fatigue and if it wasn’t for black market medications I would still be stuck in bed until I ran out of money by which time the only state help I could expect is assisted suicide - which made the choice for me. Myostatin inhibitors peptides like follistatin 344 are pretty pedestrian compared some of the stuff I’m on. I would die long before the meds I’m on would get FDA approval.

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How does one go about doing this? Are these RCs or more black then that?

Follistatin 344 is a research chemical / peptide, most of what I take now is gray market. In some places there are new laws specifically targeting research peptides which would make it black market.

It’s getting easier and easier to synthesize peptides with things like desktop chemistry and recombinant synthesis. And there are things like DNA/RNA aptamers that can be printed out at scale with Oligo sequencers so if you know the recipe quite often you can find a jurisdiction that’ll make it for you in bulk for a reasonable price.

Quite curious what research chemicals you've used against chronic fatigue (I thankfully don't have it or need medication)

The ipa/modGRF/Frag/BPC157/TB500 stack is pretty common and does help. T3 and Test can help but are not research peptides. Then there are the Khavinson signaling peptides which are coded in human DNA and known bioactive, but can be a bit dangerous. Not for the faint of heart. Most of the benefit I have gained is from psychopharmacology which is near impossible to get scripts for so I get gray market supply instead; low dose naltrexone, low dose modafinil (better than low dose abilify in my opinion), and amitriptyline. It’s not just what you take it’s also how you take them. To avoid dysautonomia you have to intentionally swing between sympathetic and parasympathetic states. I think there is a subclinical insulin resistance so meds like metformin and semaglutide (ozempic) at really low doses can help. TUDCA is good but over the counter. Im mostly back to normal but still get rough patches on occasion. As someone who is vax injured I’m interested in ACE-2 ligands which are supposed to help reverse the damage done by the spike protein. I’m also interested in off label use of copaxone. It’s massively complex and many people with this are readily willing to take deadly risks in trying new things so underground patient groups are far ahead of the doctors. We’ve already done bigger trials of some ‘promising’ new meds and already know they don’t work. It’ll take medical science many decades to find out the same thing. I have hEDS by way of multiple TNXB variants which have specific personality side effects (like Sheldon Cooper from Big Bang Theory) so it’s pretty easy to find other people with it as we almost always get ME/CFS and we react differently to specific medications - for some there is a resistance to anesthetics. I think in time the brain/gut axis with microbiota biome/virome being important. So diet and a phage cocktail could help as well as a targeted antibody neutralizing small molecules to fix specific autoimmunity problems. These are whole categories of potential medicines which are largely ignored my mainstream medical science.

Dallas Buyers Club vibes

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