If I can wear that while being physical I can probably handle the Vision Pro for extended periods.
The Quest 2 wasn’t that comfortable to use out of the box, but after adding a Vive Deluxe Audio Strap connected with 3D printed adapters (which distributes weight better) and a counterweight that’s attached the back of the strap it’s dramatically improved. Still not perfect, but I have no issues wearing it for an hour or longer playing Beat Saber.
But I just don't think weight alone will be a concern given my experience with the Index.
My only problems with the index is the weight distribution while moving around (particularly while playing beat saber and crouching) but I likely wouldn't be doing that with the Vision Pro. And heat while being physically active but that was easily solvable by adding a fan to the front.
I already use this thing almost every day. But maybe that's because I am used too it so the jump to something like this is not really that crazy.