Yes and no. The basic flight path would not change, but it does get affected by weather conditions and such. So the drill would be that they get the weather data and other inputs, and would need to provide the guidance set up parameters.

He also told that they’d also do drills where they need to hit an actual target on the other side of the Soviet Union with an actual ICBM. Some kind of a polygon made for such drills. If I recall correctly, getting it within a kilometer was considered acing it.