This also means if you manage to clone a remote, you can just abuse humans. If you opened the door with your clone, the next time the original remote sends its package the sequence number will be too low and the controller will ignore it. But what do you do if your remote didn't work? You press it again, this time the sequence number matches and things work as they should.
For cloning you need to reconstruct the initial seed for the PRNG that is used to create the ciphertext based on the sequence number. Based on how little resources these remotes tend to have, more based on cost than battery life etc, and that some vendors design their own crypto, this can actually work. If you know the algorithm and the seed is only 32 bit, you can easily brute force it.