It's a complex topic. I think it really got kicked off with "What is Life?" and we've been able to build more details on it since then. There are many parts of the story that we know in incredible details. Chaos theory, information theory, non-equillibrium thermodynamics, complexity and emergence, auto-catalytic chemistry are all just parts of it, and each one are massive fields of study on their own.

I'm not sure there will ever be a synthesis of all these things that creates a paradigm of some sort. There's simply too much.