Oh, cool- they turned a not-truly-a-knot (open ends) protein into a truly knotted one (connected ends) and then unfolded it using urea and it stayed knotted. That's what you'd expect but it's also pretty cool.

Protein design is a multi-billion dollar field.

A single observation- thermostable proteases- was incorporated into modern laundry detergents, making Genentech and Corning billions of dollars in IP.

A category theory textbook opens the "motivation and use cases" section with the following poem:

There's a tiresome young man in Bayshore. / When his fiance cried 'I adore / the beautiful sea' / he replied 'I agree, / it's pretty, but what is it for?'