This resonates given my love of dogs and the huge chain of complex events that likely connects the sewage plant effluent that fertilized the lawn where I lived as a child and my emergent disease states that followed.
Ignoring the fact that exposure may be a problem from E. coli to sewage, I read Robynne Chutkan's microbiome book at the suggestion of my doctor several years ago and nothing has come closer to the truth on our lack of exposure also being part of the problem.
You're damned if you do and damned if you don't. Try finding the median there and there's a Nobel waiting for you.