Interesting Twitter Hashbang Bug
shkspr.mobi
shkspr.mobi
It's purely cosmetic and meant for search engines (as noted in the article) and easy readability.
For SEO and UX the current scheme is good. So they should keep using it.
But the problem is thinking that "we use REST so every darn resource on the site has to follow this pattern even though it makes no sense to use it"
I don't think twitter is going to filter by user to see if it matches the url. The key for the tweet is the tweet_id and that's the key to their (hugely cached) DB
Perhaps in the future you coud have fun with that by associating certain content with people’s Twitter account names. Not sure what affect it would have though. :)