I have historically expressed trepidation towards external attempts to "fix" Python packaging, largely because each attempt has historically accreted another layer of incompatibilities and hacks onto the giant pile of hacks that are already needed to keep the ecosystem running. As such, it makes me happy to see that compatibility is a priority here: the Astral team has gone out of their way to emphasize both formal (PEP) and informal (pip CLI) compatibility with existing tooling and standards.
(Separately, I share concerns about VC funding and sustainability. But everything I've seen so far indicates that Charlie and the other folks at Astral are not in it to screw or otherwise leverage the Python community. So I choose to be optimistic here.)