Somewhat tangent - I've lost about 20% on semaglutide. What I discovered, since I lost quite a lot of muscles as well, my lower back pain, related to crack in one vertebrae, got really bad. Once I reached my weight goal (just a hair above "normal" weight, coincidentally where I plateaued), I started weights lifting, starting at very low numbers, and keeping semaglutide at about half dosage. It seems to help so far.

Just something to consider for someone who need to lose a lot of weight and who has some underlying condition. It is still worth it in my opinion, just not as painless as one could think.