I’m not too partial to nested tabs, but I think “panes” (Firefox extension Sidebery nomenclature) or “spaces” (what Arc calls them) where you can swap what group of tabs (including pinned tabs) is represented by the tab sidebar with a click is powerful, particularly combined with association of a pane/space with a browser profile.
So for example, a single browser window can switch between being dedicated to general browsing, shopping, online university courses, or software development, and if I want to split a pane/space into a new window temporarily, this is possible too.