There are a few reasons for that. (1) There's no tab abuser worse than me. I have hundreds of them around (I have commented before, why I have it that way) (2) I do all my browsing from a (battery less) laptop with 512 MB of RAM. (3) I do not close my browser for months on end. On top of that I expect that I should be able to do my usual editing etc while I have the browser open.
For this very corner'est of corner cases, if I use Chrome, my box goes into a fetal position and dies. However, and kudos to FF 3.6, (yeah 3.6!) my laptop works great, no problem at all. I have flashblock, no script, bar-tab, memory fox, bunch of greasemonkey scripts (to fix google's layout, and give github and bitbucket a dark theme) and have tweaked FF's cache settings.
On a more performant box I am on FF-11, but have never upgraded on the other, fearing that the new FF assumes (not unreasonably) the box to have more memory.