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Once you plug long term storage onto your Prometheus, do you really need the main Prometheus instances anymore?

Here’s an article about this idea: https://datadrivendrivel.com/posts/rmrfprometheus/

You can substitute the Grafana Agents for OTEL collectors as well.

While Grafana Agent uses less resources than Prometheus, there is more optimized Prometheus-compatible scraper and router exists - vmagent [1]. I'd recommend you giving Grafana Agent and vmagent the same workload and comparing their resource usage.

P.S. Prometheus itself can also act as a lightweight agent, which collects metrics and forwards them to the configured remote storage [2].

[1] https://docs.victoriametrics.com/vmagent/

[2] https://prometheus.io/blog/2021/11/16/agent/

That's just kicking the can over to an object storage API instead of managing disks.

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