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The Tleilaxu are the only ones who make gholas until Heretics or Chapterhouse, and there is definitely a prominent ghola in book one.

We don’t see face dancers or high level negotiation with the Tleilaxu in book 1, that I agree with.

Second book, there are no gholas in the first book. They're introduced as a concept (and with a character) in Dune Messiah.

Wow! I can’t believe I misremembered that so confidently. You’re right. So, my whole comment was wrong; no Tleilaxu until Dune Messiah.