This is interesting -- one thing that people on HN also pointed out was the possibility of GLP1 gene therapy. It was the first I heard of it but:

The original comment (thanks to toomuchtodo):

https://news.ycombinator.com/item?id=39354361

Some follow up links:

https://news.ycombinator.com/item?id=38495653

https://news.ycombinator.com/item?id=39284781