Maybe; hopefully he can sell whatever stake he has in OpenAI to avoid conflict-of-interest concerns. Personally I can hardly think of any better person for the role.
I can think of an entire body of people who should be excluded from such a role; people who spent multiple years working at OpenAI.
That would be great, but I don't think federal appointees are ever forced or even asked to divest anything. At most he'd just have to disclose the conflict of interest.