We know for sure that there are issues with our current theories. Our two best theories, general relativity and quantum mechanics, are not compatible with each other.
https://en.wikipedia.org/wiki/General_relativity#Relationshi...
https://en.wikipedia.org/wiki/General_relativity#Relationshi...
< atomic and > planetary have very important applications!
But I'd argue not nearly as many as "Here are all the formula that govern a falling apple."