Getting to the airport really stood out. I thought of it as a two-hour trip, because I had to walk to a bus, then transfer to a train, then another train, then another bus. It took less than half an hour in a car. As a student, the difference in fare between mass transit and a taxi was enough that I couldn't swing it (dating myself--this was before Uber/Lyft), but I had essentially been trading my time for an extremely low amount of money when I look back at it.
I know a couple who live in SF without a car, as much as a statement as anything else. And I see them making a lot of use of Uber, Zipcar, conventional rentals, and weekend visitors who have a car.
If I booked my flight to campus at the beginning of the school year with a very tight connection somewhere, I could run and make the flight, but my luggage would not. Then they would have to deliver it to me at my dorm in a day or two when it arrived!
I would just pack enough for a couple days in my backpack and wait for my suitcases later!
I wouldn't not want to have access to a car, but if car/truck rental wasn't such a mess, I would be happier without one. (When I bought this place I cut back the 4+ car driveway to two cars and reclaimed a bunch of yard, and it was great. I wish it could've been more!)