It's an important point. We've ended up using two Hilbert curves, rotated by 90 degrees to tackle this problem. If it is close on either, it is close in 2D space
BOTH cartesian coordinates / EITHER Hilbert coordinate
And that being far apart in 2D space corresponds to being far apart on
EITHER cartesian coordinate / BOTH Hilbert coordinates
But if we consider the two commas below which are close together in 2D space, we see they are far apart in any rotation of this Hilbert curve?!
__ __ __ __
|__| __| |__ |__|
__ |__ __| __
| |__ __| ;__ __| |
|__ __,__ __ __|
__| |__ __| |__
| __ | | __ |
|__| |__| |__| |__|