Implementation difference. Threads are usually handled by the kernel and each one has its own stack where you can put anything. And the kernel can switch threads at any time. Async/await has the compiler work out precisely what has to be saved across the marked locations which are the only places context switches can happen. Also it doesn't tell the kernel when it switches context.

Await-async is implemented with a runtime which uses a thread pool or a single thread and allocates work when needed on any thread and waits for IO to yield a result.

With threads you just fully control what blocking code is running on a single thread.

If you are just running computations (or reading files, as filesystem api are not async) it's simpler to just use threads.

Yes, they are different in most cases.

In general await job is to pass the process to 3rd party e.g. database or http and wait for callback whereas thread job is to launch multiple CPU operations in parallel.