I spent a good portion of the past 40 years hiring people (certainly not full time but as part of my primary responsibilities).

A stint trying to establish your own business would definitely attract a large part of my focus during any interview. I'd need to satisfy myself I knew the truth why you went out on your own. In particular I'd need to believe your reason was excitement about something particular you were going to do; and not because you were running away from something (unemployment; boredom with work; difficulty not being the boss; etc).

On the other hand, I'd be really interested to hear about the thing that attracted you so much and everything about that experience. I suspect I would find that experience an overall positive.