It's my belief this applies only to the custom software. I saw reviews online of people using the Famicon version on OSX, using OSX's native keymapping to switch cmd&option around.

I pre-ordered a C64 version, hopefully my suspicion is correct because I plan on taking this to work for use on a Mac.

Works great on Mac and it has firmware-based key mapping/macros which worked great for me to physically swap some keys and remap them to get the correct Mac key placement. This is persistent across machines. The software to do this is windows only, so you’ll need access to a windows pc or virtual machine once. There are physical buttons for remapping but I think they only work for remapping the 2 big external buttons.