"Is this a fail-safe path? Of course not. Even in chess. The rest of the game does matter."
I also think his framing is somewhat misleading, since the default mindset (Despite his hedging) is that you will win (Or have higher chances) if you don't blunder.
The problem is that winning in startups is often a tail event, which means reducing blunders doesn't have much impact on the overall probability. Is reducing blunders the highest order bit?
"An entrepreneur may look at a successful diner and think that customers are there because of the hip decor on the walls. She sets up a competing diner across the street with better decor only to find that it can't pull any customers away. The highest-order bit isn't the decor. It's actually the cheap but high-quality coffee that customers care most about. Without getting the coffee right, no amount of aesthetics will beat the competition."
https://commoncog.com/highest-order-bit/
The only time this is a winning strategy is if survival has compounding effects. For startups, they tend to be default dead.
This memo by Howard Marks explores the case when survival is actually a winning strategy:
"If we avoid the losers, the winners will take care of themselves"
https://www.oaktreecapital.com/insights/memo/fewer-losers-or...
Reducing blunders is obviously good in any situation, but is it the dealbreaker for startups? It always depends on the context.