Thumbnails at a high pixel density. I just want them up fast. Any quality that can be squeezed out of it is a bonus.
If you must use JPEG, I suspect you might get better visual quality by halving the resolution and upsampling on the client.
By doing so, you are effectively setting the lower and right halves of the DCT to zero (losing all high resolution info), but get to have 32x32 pixel macroblocks which lets you better make use of low frequency spacial patterns.