Anything that has to run on a BSD or a Mac needs these tools
Do QEMU, tcc, and OCaml run on BSD and Mac? Pretty sure they do
https://news.ycombinator.com/item?id=39925033
https://github.com/lucasaiu/ocaml/blob/master/configure
They have hand-written configure scripts, and don't use autoconf.
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Also, https://www.oilshell.org/ runs on BSD and Mac, and it doesn't use autoconf. The configure script is a few hundred lines of "boring" shell.