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Thanks! How much more cumbersome does the lock make it to use Tailscale?

Not much. You first add the host and then you need to either click the link that will open the Tailscale app to sign the host or you run a command.

If you use Mullvad VPN you need to sign the Mullvad exit nodes.

Just make sure to have more than one signing device in case something happens to your main computer.