In the '00s and early '10s there was a London startup, Resolver Systems [1] , that was trying to bring Python and spreadsheets together. Alas they didn't make it but I wonder if that was because Python had a much smaller mindshare back then.
I think they are some of the same folks who later founded PythonAnywhere, which I had also tried.
I read recently somewhere that they were acquired by Anaconda.