1. The propane they are manufactured with is carefully dried, but propane out of bulk tanks is not. The single use tanks have thinner walls with less corrosion protection because the high-end propane doesn't need it.
2. The safety over-pressure valve on those tanks has similar design constraints and may corrode shut with un-dried propane. Sometimes people damage those valves while refilling.
3. It's easy to overfill those little tanks such that high temperatures can cause over-pressure problems. Due to (1) and (2) the built-in safety measures for refillable tanks cannot be assumed.