Ideally I'd have both (5k 27" 144Hz or 6k 32" 144Hz), but such a screen from a reputable brand seems to be a unicorn. Then I prefer higher PPI over higher refresh rate.
The initial 60hz feel is jarring but you quickly get used to it. At least that's the case for me.
If you are a Mac user then you have to compromise though, 4K at those sizes isn't dense enough to meet Apples ~220dpi Retina standard, and the monitors that do meet that standard are all limited to 60hz (and hideously expensive). You either have to deal with Apples janky fractional DPI scaling, or put up with 60hz for now.
If you don't notice it then that's fine, but some people do, particularly if they are used to Windows' pixel-perfect fractional scaling.
However, another reply said the built-in display is likely fractionally scaled as well; I hadn’t considered that at all, so I’ll have to set it to 2x if so, and see if I notice a difference.
• Microsoft Remote Desktop (with "Optimize for Retina displays" enabled and RDP host settings optimized for quality) is usable and looks good, but things that rapidly change large sections of the display, like dragging windows around, have noticeable lag. Though this lag is generally only reduced, not eliminated, at native resolutions, so changing modes in this case is rarely worthwhile, and the Windows applications I use most (Visual Studio, JetBrains Rider, and Windows Terminal) run well enough that I choose to work via 1440p-like Remote Desktop 99% of the time even when a local connection is only a KVM switch away.
• Playing back 60 FPS videos in mpv with high quality presets and scaling algorithms drops frames. Default settings and lower frame rate videos both work fine, and in light of Retina superscaling, the quality difference is negligible, so I change mpv settings rather than scaling settings in this case.
• While not a performance problem, displays from OSes designed with pixel-perfect rendering in mind (e.g., classic Mac OS, NeXTSTEP) look bad at higher-than-VGA resolutions. The only scenario where I typically switch to another scaling mode is when emulating these.