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I'm curious what the challenges are around using mRNA to synthesize antibodies in a person's own cells. A little googling turned up this company: https://acuitastx.com/technology/mrna-therapeutics/ but I'm curious if there are any obvious showstoppers for that kind of thing.

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I assume the main issue is that antibodies are produced by B cells and probably wouldn’t be functional if produced by the muscle cells that are the traditional mRNA target. And it would be transient, your immune system wouldn’t learn to make that antibody (maybe a feature for a drug).

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