a) Spreadsheets. Not talking about simple stuff here, Libre/OpenOffice is a joke when it comes to more advanced stuff, and whether we like it or not, the world is literally running on spreadsheets. Google Sheets is okay for less demanding tasks, Apps Script is a huge plus of that platform.
b) 2D graphics and photography software. Adobe CS is unfortunately still irreplaceable, even 20 years later. Again, I'm talking about professional graphic design and photography work (and workflows). Yes, there are masochists trying to do DTP on Linux. Yes, people think AI will replace those jobs. Neither will happen in the foreseeable future. Take typography as an example of such a highly specialized craft. Which is why Adobe (and some others) can afford to be so damn aggressive with their policies.
Wine doesn't cut it. I often wonder if anybody really uses it for anything except messing around.
Hence the only solid alternative is macOS.
On the other hand, all this also means opportunities... :)