I've been prescribed just about any ADHD medication you can think of, but they all pale in comparison to solid coping mechanisms. I know my options are basically adderall or vyvanse, and I know how I react to them.
Caffeine is a decent substitute most days. What it comes down to is my aversion to the physical response of amphetamine, as well as the long-term implications of blasting my brain with speed every day. I haven't had any drug problems, I take a rational, knowledge-driven approach to the disorder. But I want to feel like I'm at 130%, not 80%. I'll probably return to vyvanse, just much lower doses than I used to be prescribed, and see how that shakes out.
It's hard for people without this disorder to really appreciate the implications. I just lost a best friend last year over his toxic behavior and insensitivity around what he believes is a made-up disease, despite overwhelming evidence for a genetic explanation involving reduced dopamine uptake.