Penrose basically thinks that biological neurons do QM magic and therefore classical computers can't do what they do.
A classical computer is only exploits a little bit of physics, so I don’t think it is obvious that we’ll ever create a classical computer that matches (however we pick the metric to match, efficiency is harder than raw compute) human intelligence (however we define that). But a machine intelligence could be designed using all of the physics we understand including quantum mechanics.
http://backreaction.blogspot.com/2024/05/brain-really-uses-q...