If you limit your variable portion to a base16 alphabet like A-P, radix encoding would just be `nibble + 0x41`. Sure you're encoding 4x as many values, but with full branch predictability. You'd have to experimentally determine if that performs any better.
You could also do something theoretically clever with bitmasking the 4 nibbles then adding a constant like 0x4141 or 0x00410041 or something (I'm too tired to think this through) and then you can encode twice as many per op assuming 32-bit bitwise ops are similar in speed to 16-bit bitwise ops.
Anyways this has been a cool challenge. You might also enjoy hunting for amulets - short poems whose sha256 hash contains a substring that's all 8: https://news.ycombinator.com/item?id=26960729