I do not know much about Flask and it looks like it has some bare bones middleware and context processor tools, but it doesn't look like it does much more than what web.py offered, well except for all the testing tools (which look pretty cool).
Sure the article has a good argument about separating components, but before you propose your alternative you should include all of those features (decoupled I suppose) that Django does for you already. In addition the patterns page[1] on the Flask documentation is basically a cookbook for things that Django already does, and by the way encourage the one code base architecture this presentation argued against.